Changing to a USB 2.0 port (a common suggestion) No Joy.
Changing to ASIO4All (another one...) fixed it but latency was unacceptable
Changing computer (ANCIENT desktop, Win 7 Home Premium, Precambrian MOTU Firewire interface) DID work (64-sample buffer), but isn't exactly portable, and my laptop doesn't speak Firewire.
Same thing here with Scarlett Solo Gen2 and latest Focusrite driver.
My Ableton Live sounds no problem so i has to be an issue with Brainspawn