have you tried increasing your buffer size? have you optimized your computer (there are tutorials here)?
i would check your soundcard's buffer setting and raise it 1 increment at a time and see if that fixes it. search this site for "PC optimization" . there is a tutorial. GL
There's also a list for windows 10
I don't think that's the issue here, though.
I used to have this same problem. Audio crackling after a scene change. Never the same scene, never at the same moment.
I never found a true answer or solution. It seemed to be related to a buffer not emptying in SolidSoundStudio's routing plugins (do you use those?) or a bridged plugin maybe.